Mazzoni Center is a 501(c)(3) nonprofit[1] health care provider in Philadelphia, Pennsylvania, that serves the LGBTQ community.

Its areas of original focus included clinical services for gay men & lesbians, health education, and advocacy work; however, responding to the AIDS epidemic became the health agency's primary concern during the 80's and early 90's.

[4][5] Dr. Mazzoni had served as the clinc's medical director, was an openly gay and HIV-positive physician, and died in 1990 at age 31.

[6] Today, the Mazzoni Center is the oldest HIV service provider in the state.

[3] In August 2017, the Mazzoni Center cancelled a Trans Health Conference panel discussion on detransitioning.