McDowell Lake First Nation (Oji-Cree: Mishi Sakahikaniing) is a small Oji-Cree First Nation band government located in Northern Ontario, located approximately 155 km northeast of Red Lake, Ontario, Canada, on the central western shore of McDowell Lake.

It is part of the Keewaytinook Okimakanak Council (Northern Chiefs) and the Nishnawbe Aski Nation.

The small community of Misi-zhaaga'iganiing was established by trapper Johnny Kenequanash in the 1940s on the central western shore of McDowell Lake, known in Oji-Cree language as Misi-zhaaga'igan, meaning "the grand lake."

The Governments of Canada, Ontario, the Nishnawbe Aski Nation and six of its member First Nations (Aroland, Keewaywin, McDowell Lake, New Slate Falls, Saugeen, and Wawakapewin) signed an agreement in December 1991 to make lands available to establish Indian reserves in the six communities and to provide basic community facilities.

Government services are provided by the Keewaytinook Okimakanak Council and by the Nishnawbe Aski Nation.