Throughout Shepparton, McGuire College is recognised as a culturally diverse school.

The student culture includes Arabic, Afghani, Indigenous Australians, Sudanese, Congolese, South African, Kenyan, Samoan, Tongan, Thai, Fijian, Italian, Chinese, Korean, Japanese and Kiwi.

McGuire College has four house groups for school sport events; Teal (blue), Crane (yellow), Heron (red) and Swan (green).

These houses compete in an Athletics Carnival, Cross Country Running and Swimming.

The school was first opened in February 1966 as Shepparton South Technical School and was first located at the Shepparton Showgrounds but it grew so quickly that it had to move to the current site of McGuire College on Wilmot Road in 1968.