McIntosh is one of the most Native American towns in Alabama, with over half of the town's inhabitants reporting to be of Native descent in the 2020 census The town and county have a high proportion of residents who are members of the MOWA Band of Choctaw Indians, a state-recognized tribe of people of the Muskogean-speaking language family.

It has one site, Andrews Chapel, listed on the National Register of Historic Places.

[5] McIntosh is near the site of Aaron Burr's arrest in 1807 while the area was part of the Mississippi Territory.

He was captured by U.S. Army Lt. Edmund P. Gaines in the town of Wakefield, a few miles to the north, and then confined to Fort Stoddert.

[7] According to the U.S. Census Bureau, the town has a total area of 1.0 square mile (2.6 km2), all land.

30.9% of all households were made up of individuals, and 11.7% had someone living alone who was 65 years of age or older.