The school was named in honor of New Orleans social activist Eleanor McMain.

[6] Students and Alumni refer to the schools appearance as "The Birthday Cake" because of its square shape and candle-like pillars.

As Hurricane Katrina was about to hit, the New Orleans Regional Transit Authority (RTA) designated McMain as a place where people could receive transportation to the Louisiana Superdome, a shelter of last resort.

In 2017, it was announced that McMain was going to become a charter school and retain the same name under the Inspire Charter Network starting with the 2018 school year.

[8] McMain Secondary School athletics competes in the LHSAA.