[2] In the 1980s, McMaster developed and coined the term "evidence-based medicine" as a way to approach clinical problem solving.

By 1966, the first five faculty members, John Robert Evans, William Walsh, Bill Spaulding, James Anderson and Fraser Mustard were recruited.

The DeGroote facility is shared with the Centre for Function Genomics, Centre for Gene Therapeutics, Institute for Cancer and Stem Cell Biology Research, Robert E. Fitzhenry Vector Laboratory, Centre for Asthma and Allergy Research (Allergen) and North American Headquarters for West Nile studies, as well as the Bachelor of Health Sciences undergraduate program.

[10] In 2016, the medical school opened the David Braley Health Sciences Centre, a 192,000 square foot building, to be used by the Family Medicine department, Hamilton Public Health and other various academic divisions of the medical school.

All three campuses offer the same curriculum and lead to the same degree, but differ in patient populations and teaching locations.

Most medical schools in North America have adopted PBL in varying degrees into their curriculum.

[12][better source needed] In the early 1990s, the School of Medicine developed the personal progress index (PPI) as an objective method for assessing acquisition and retention of knowledge for students in the medical program.

Due to the overwhelming success and research supporting the use of the PPI as an evaluation tool, it is now used in Canada, US, Europe, and Australia.

The MMI has consistently shown to have a higher predictive validity for future performance than traditional interviews.

In 2010, McMaster began using a computer-based simulated test known as CASPer as an admissions tool at the pre-interview stage.

This is an assessment of interpersonal and decision-making skills that is more reliable, and predicts much more validity than standard autobiographical submissions.

[17] The Michael G. DeGroote School of Medicine received over 5200 applications in 2014 for a class size of approximately 200 students.

The pre-clerkship curriculum is divided into five medical foundations, where students meet with a faculty member twice a week in a small group setting for teaching.

[20] McMaster is considered a leader in clinical epidemiology and thrombosis research with names like Dr. Jack Hirsh, Dr. Salim Yusuf leading the way.

The American Society of Hematology and McMaster University are collaborating to release the official guidelines on the treatment of venous thromboembolism in 2017.

In 2019, the Juravinski's pledged to donate an additional $100 million to the medical school and create the Juravinski Research Centre, funding research in areas including cancer, mental health, lung and respiratory care and diseases of aging.

In 2011 and 2012, the Boris Family donated a total of $41 million to McMaster University Medical School and St. Joseph's Healthcare Hamilton to found the Boris Family Centre in Human Stem Cell Therapies, establish two chairs in Blood and Neural Stem Cells, found the Boris Clinic, fund alcohol addiction research and buy a surgical robot.