Md Isa bin Sabu (born 24 August 1946) was the seventh Chief Minister of the Malaysian state of Perlis, in office from 2008 to 2013.
He held the state assembly seat of Bintong, in the Perlis capital of Kangar, until his retirement from politics in 2013.
Md Isa was sworn in as Chief Minister of Perlis on 17 March 2008 following the 2008 Malaysian election.
The Raja of Perlis appointed Md Isa despite Perlis UMNO leader Shahidan Kassim having a letter of appointment from Prime Minister Abdullah Ahmad Badawi.
Md Isa claimed the support of eight of his fellow UMNO assemblymen, satisfying the Raja that he could command the support of a majority of the 15-member Perlis state assembly.