In 1795, Empress Catherine II of Russia granted Charlotte von Lieven (1742–1828), the tutor of her grandchildren, a lifetime use of the property at Mežotne.

During the last years of the Duchy of Courland's history, the manor was rented by Johann Friedrich von Medem.

After the death of Charlotte von Lieven in 1828, the manor was inherited by her son Johann who had returned to Mežotne in 1817 after his military service in the Russian army.

He started his career in St. Petersburg, but when he attained the rank of lieutenant of the Guards Cavalry, he left the army and settled in Mežotne.

In 1920, Prince Anatol Lieven was dispossessed of the estate as a result of the Latvian government's agrarian reform.

During World War II, the manor was partially destroyed by artillery shells fired by the Soviet army in 1944.

In 1996, the house was transferred to the control of the State Real Estate Agency, which carried out extensive reconstruction and restoration work in 2001, and a hotel opened.

The facade to the front has a portico with four columns, the part to the park has a semi-rotunda that both correspond to the design by Giacomo Quarenghi.