"Me, Myself and I" peaked at number four on the US Billboard Hot 100, becoming Beyoncé's fourth consecutive top-five single in the United States.

[5] A CD single was released on October 21, 2003, in the United States, which contained Junior Vasquez's dance radio mix of "Krazy in Luv" as its B-side.

[8] The single was released in selected European countries in January 2004, including Austria,[9] Belgium,[10] Ireland,[11] the Netherlands,[12] Sweden,[13] and Switzerland.

[16][17][18] In 2004, the single was also released in the United Kingdom on an enhanced CD that included videos of live performances of "Naughty Girl" (2003) and "Work It Out" (2002).

[25] In an interview with Corey Moss of MTV News, Beyoncé explained the lyrical content of the song: ... [Me, Myself and I] basically talks about a girl who the guy's not right for her and he's cheating and whatever.

And usually women feel stupid and silly and they blame themselves 'cause you have all the signs most of the time, but you love the guy so you don't want to see them go.

And in this song, it's kind of like a celebration of the breakup ...[28] According to Neil Drumming of Entertainment Weekly, "Me, Myself and I" is similar to "Say My Name" (2000), in terms of " ... its specificity and earnestness ... " and the way Beyoncé defends " ... her chastity [a]gainst some greedy boy ... .

Music who wrote that the song hints at what is to come as the warbling begins to move into overdrive on " ... a faintly sickly, if admirably slick, ode to that old Destiny's Child staple ... ", independence and self-belief in the face of a cheating man.

"[31] Ryan Schreiber of Pitchfork Media noted the song as the "most notable 80s throwback" of the album, as its "augmented chords" call to mind Patti Austin and James Ingram's 1983 single "Baby Come to Me" and Michael Jackson's 1983 single "Human Nature", or a decelerated version of "Baby Be Mine", from Jackson's 1982 album, Thriller.

[32] Spence D., writing for IGN Music considered "Me, Myself and I" as a typical sounding R&B ballad with a familiar theme, and in which Beyoncé sings with passion.

[40] It stayed in the UK Top 100 for seven weeks, and was the second shortest presence on a singles chart, after her 2009 duet with Lady Gaga on the extended remix version of "Video Phone".

[45]When some of the behind-the-scenes footage was used in a BET Access Granted special, some of the scenes that Beyoncé was shown shooting did not appear in the finished video.

[45] The footage follows the plot of the song's theme, in which Beyoncé deals with a cheating boyfriend when she finds his mistress' red panties.

[49] During the Verizon Ladies First Tour which also featured Alicia Keys, Missy Elliott and Tamia, Beyoncé performed "Me, Myself and I" in New York City to an audience of over 20,000.

She shouted that she wanted to hear everybody from front to back, and continued singing, then told the audience that she wrote the song for "each and every one of y'all!".

[53] Jon Pareles of The New York Times complimented the performance, stating: "Beyoncé needs no distractions from her singing, which can be airy or brassy, tearful or vicious, rapid-fire with staccato syllables or sustained in curlicued melismas.

But she was in constant motion, strutting in costumes (most of them silvery), from miniskirts to formal dresses, flesh-toned bodysuit to bikini to negligee.

"[54] Shaheem Reid of MTV News also praised the performance, and wrote: " ... For all the dancing she did, Beyoncé got an equally big — if not more resounding — response for displaying her undeniable vocal ability on the ballads like "Me, Myself and I".

"[53] In Los Angeles, Beyoncé gave a full-length performance of "Me, Myself and I" without backup dancers and with limited live instrumentation.