In an interview with Zane Lowe, Sumney revealed about the production of the track:[1] "Upon playing the demo for 'Me in 20 Years' for Dan Lopatin (Oneohtrix Point Never), he told me it sounded like an old lady screaming to herself in the middle of Whole Foods.

[2] Lyrically, the song tackles how Sumney wonders and asks questions about his life in twenty years, highlighting the absence of romantic lover and being alone.

[3][4] Martin Colino of Blanc Magazine stated the song "evokes the surreal mind space of a heartbroken lover imagining their future with, or without, their partner, unable to decide which fate would be worse".

[7] While reviewing the associated album, Jenessa Williams of DIY praised Sumney's vocal performances, calling them "plucking glorious, impossible high notes out of the ether".

[9] The Observer's Kitty Empire called "Me in 20 Years" as the "sucker punch" of the second part of græ, further praised Sumney's vocal performances.