[5] The Charles F. and Howard Cates Farm, William Cook House, Cooper School, Cross Roads Presbyterian Church and Cemetery and Stainback Store, Durham Hosiery Mill No.

[10][11][12][13] In 1939 as part of the New Deal, Margaret C. Gates won a competition sponsored by the Section of Painting and Sculpture of the Treasury Department to create a post office mural in Mebane.

Her painting, Landscape—Tobacco Curing, which showed a man and a young boy walking in tandem on their way to work on a tobacco farm, was completed and installed in 1941.

A local artist, Henry E. Rood III, was hired to create an exact replica of the painting to adorn the new facility.

[14] While the North Carolina Department of Transportation had long-standing plans to reroute North Carolina Highway 119, currently running through the city's downtown, to a new alignment further west, concerns in predominantly African-American communities along the proposed route, combined with longstanding dissatisfaction with access to municipal services, resulted in civil rights complaints being filed by the West End Revitalization Association and other local residents against the Department of Transportation and city government.

[15] Although a four-year moratorium on the project was established in 1999, the Federal Highway Administration eventually granted approval in December 2009.

[16] In October 2014, the city council voted to adopt a new seal and slogan, replacing "A progressive community, the perfect place to call home" with "Positively Charming".

Reflecting that the city is split between two television markets, Spectrum's Mebane system offers stations from both the Triad and Triangle.

DirecTV, Dish Network and U-verse customers receive the Triad local feed, since most of the city is in Alamance County.

A Tanger Outlet mall is located on Arrowhead Boulevard on the north side of I-85 in Mebane.