The name of the brigade was chosen to commemorate the twelve Battles of the Isonzo during World War I.

In 1975 the Italian Army undertook a major reorganization of its forces: the regimental level was abolished and battalions came under direct command of multi-arms brigades.

As tensions with Yugoslavia over the city if Trieste were allayed by the Treaty of Osimo and because of a reduction of military service from 15 to 12 months for army and air force and from 24 to 18 months for the navy, forced the army to reduce its forces by nearly 45,000 troops, it was decided that the units of the Infantry Division "Mantova" would contract to a single brigade.

After the activation the "Isonzo" brigade entered the Mechanized Division "Mantova" and consisted of the following units.

As the Mechanized Division "Mantova" carried the traditions of the 104th Infantry Division "Mantova" and Combat Group "Mantova", which both had fought against the Germans during the Italian campaign of World War II the army decided retain the name of the division.