The district, mostly in Grant County, includes Medford, Manchester, Renfrow, and Wakita, as well as portions of Jefferson.

[citation needed] The district's territory extends into Alfalfa County.

The Encyclopedia of Oklahoma History and Culture stated it was "apparently the first in Grant County".

Athletic programs hosted by the school include softball, basketball, baseball, football, track and field, cross country, and golf.

Medford Schools’ influence has grown over time as districts such as Wakita,[10] Jefferson, and Renfrow high schools have been absorbed due to population decrease.