Shankr made her acting debut with the British miniseries Beecham House (2019) and followed it with supporting roles in the film Shaadisthan and the series Dil Bekaraar (both 2021).

[7] Shrishti Negi of News18 opined, "Medha channels a teenager’s vulnerabilities and simmering frustrations with utmost honesty".

[8] That same year, she portrayed the youngest sibling, Eshwari, in the streaming series Dil Bekaraar, which received positive reviews from critics.

[10] In 2023, Shankr portrayed Shraddha Joshi, an UKPSC officer in the drama film 12th Fail, opposite Vikrant Massey.

[11] Bhavna Agarwal of India Today noted, "Medha Shankr as Shraddha, has a defined part as well, and she is the crutch that helps with lighter moments in the film".