Shankr made her acting debut with the British miniseries Beecham House (2019) and followed it with supporting roles in the film Shaadisthan and the series Dil Bekaraar (both 2021).

She achieved her breakthrough with the biographical drama 12th Fail (2023), which won her the Zee Cine Award for Best Female Debut.

[8] That same year, she portrayed the youngest sibling, Eshwari, in the streaming series Dil Bekaraar, which received positive reviews from critics.

[10] In 2023, Shankr portrayed Shraddha Joshi, an UKPSC officer in the drama film 12th Fail, opposite Vikrant Massey.

[11] Bhavna Agarwal of India Today noted, "Medha Shankr as Shraddha, has a defined part as well, and she is the crutch that helps with lighter moments in the film".