The institute was established on 28 January 1835 by Lord William Bentinck during British Raj as Medical College, Bengal.

[2] In 1947, Sree Dhiraranjan Sen, a student of the college, died during a Vietnam Day police firing.

[3] The Vietnam Students’ Association passed a resolution in its Hanoi session in memory of Sen in March 1947.

[5] Between 1946 and 1952, the college's doctors stood for communal harmony and worked hard in the refugee colonies.

[10] In February 2023, Dr. Sudip Das, a professor of ENT Department from the institution, gets a patent for developing a simple and innovative device.