The Clinic was founded in 1871 as a weekly journal by the faculty of the Medical College of Ohio.

J. C. Culbertson gained control over it in 1878, and merged it with the Cincinnati Lancet and Observer, forming a combined weekly journal, the Cincinnati Lancet and Clinic, of which he and James G. Hyndman were the initial editors.

Along with a weekly publication, the journal also released a volume of works biannually.

The volumes were separated by dates, with the first covering working from January 1 to June 30 and the second July 1 to December 31.

[1] The journal ceased publication in November 1916, citing financial difficulties.