[7] Styles said that the song did not appear on Fine Line or Harry's House because even though he finds it "very fun to play live", he feels that "sonically it's just not really where [he's] at anymore".
[14][3] Owen Myers from The Guardian called it "an important moment for some bisexual music lovers, unaccustomed to seeing their own experiences mirrored in arena-filling pop songs.
"[3] The song has been seen by some critics as part of a wider trend of accepting bisexuality and expressions of sexual fluidity in popular music.
[21] Styles performed "Medicine" on select nights during his Love on Tour 2022 residency shows in New York, Austin, Chicago, LA, and Little Rock, Arkansas, also in Brazil, on the last concert of the year, in São Paulo and New Zealand.
[1] Lilly Pace of Billboard described the song as an "LGBTQ anthem", "a crowd favorite" and, prior to the release of Fine Line, said it was on her "wish list" for his second album.