"Medicine" is the first promo single of American hip hop recording artist Plies' fourth studio album, Goon Affiliated.

The hip hop track features American singer-songwriter Keri Hilson.

The original version of the song was by Three 6 Mafia ft. Gucci Mane & Keri Hilson under the same title.

The song contains a sample of "Ex fan des sixties" by Jane Birkin and composed by French singer and songwriter Serge Gainsbourg.

It takes place in a hospital where Keri Hilson plays a nurse and Plies is the doctor which makes reference to the song.