A post office was established at Medina in 1880 and the community developed a gin, a corn mill, a hotel, a private bank, three general stores, and two churches serving 150 residents by the end of the next decade.

The population of Medina jumped to 400 by 1914, which then plunged to 250 when the Great Depression forced people to search for new jobs in the early 1930s.

It did manage to recover from the Great Depression, with the population growing to 475 by the late 1940s, with several businesses and four churches.

Besides raising livestock, residents also had recreational hunting leases up until apple farming was brought to the area in the 1980s.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.