The name Meeandah comes from the English word "meander", after the twisting and turning route of the nearby Brisbane River.

Passenger ships of the Orient Steam Navigation Company—later P&O—used the Pinkenba wharf, and special trains ran from Brisbane.

Following protests to Railways Commissioner Davidson by local residents and workers, the station was reopened in 1931 as an unattended gate.

The HMS Nabreekie Mobile Naval Air Base and a large army camp defence storage and warehouse facility were located near Meeandah railway station during World War II; the army camp remains today as the Damascus Barracks.

All passenger services on the line were suspended on 27 September 1993 by the Goss Labor government, as part of its rationalisation of the state rail network, involving the closure or suspension of services of unprofitable and underutilised rail lines.