Among her classmates were noted future actors Tõnu Aav, Mikk Mikiver, Maila Rästas, Aarne Üksküla, Madis Ojamaa, Jaan Saul, Ines Aru, and Mati Klooren.
She made her stage debut in 1961 in a production of Pedro Calderón de la Barca's 1636 play The Phantom Lady while still a student.
Among her more memorable roles in works by international authors and playwrights include: Molière, Ibsen, von Goethe, Chekhov, Strindberg, Vonnegut, Leo Tolstoy, Peter Shaffer, Jean Genet, Johannes Linnankoski, William Gibson, Alexander Vampilov, Elias Lönnrot and John Boynton Priestley, among others.
[3] Meeli Sööt made her film debut in a small role in the Kalju Komissarov directed Soviet-Estonian crime-drama Tavatu lugu for Tallinnfilm.
This was followed by a starring role as Marta in the 1982 Veljo Käsper directed drama Pihlakaväravad, opposite actor Heino Mandri.