Picking up after the events of Megamind vs. the Doom Syndicate (2024), the series features Megamind defending Metro City with the help of his friends, Ol' Chum, Keiko, and newly elected Mayor, Roxanne.
The series chronicles the new hero's quest to become a social media influencer and a true superhero.
[9] On August 5, 2022, Simons confirmed that the show's writing was completed, and production was moving forward.
[11] In February 2024, it was announced that the series, now titled Megamind Rules!, would be released on March 1, 2024.
Keith Ferguson, Laura Post, Josh Brener, Maya Aoki Tuttle, Emily Tunon, Talon Warburton, Scott Adsit, Chris Sullivan, Tony Hale, Jeanine Mason and Adam Lambert were announced as part of the cast.