[6] Her second feature The Off Hours world premiered at the 2011 Sundance Film Festival[7] and went on to receive a nomination at the 2011 Independent Spirit Awards for Ben Kasulke's cinematography.

[9] The Stranger newspaper wrote, "Griffiths navigates the horrifying facts of her film with great respect," and her direction was described as "a veritable master class in how to make humane art out of inhumanity.

The film, shot in Seattle, starred Toni Collette, along with Thomas Haden Church, Oliver Platt, and a cameo by Johnny Depp.

[15] Her sixth feature Sadie starred Sophia Mitri Schoss, Melanie Lynskey, John Gallagher, Jr., Tony Hale, Danielle Brooks, Tee Dennard, and Keith L. Williams.

"[16] I'll Show You Mine directed by Griffiths and starring Poorna Jagannathan[17] and Casey Thomas Brown[18] had its debut at Seattle International Film Festival on April 16, 2022.

[28] "Missionaries" was nominated for a 2018 GLAAD Media Award in the "Outstanding Individual Episode" category for its portrayal of two Latter Day Saints companions who begin to question their stereotypes on sexuality.

[29][30] Later that year, Griffiths directed one episode of Epix series Graves starring Nick Nolte and Sela Ward titled "They Die Happier" which premiered on December 3, 2017.

[39] Griffiths directed one episode of USA Network series Dare Me starring Herizen Guardiola and Willa Fitzgerald titled "Fog Of War" which aired on March 1, 2020.

[40][41] She also directed two episodes of the Netflix series Trinkets starring Brianna Hildebrand titled "Same Time Last Year" and "Black Friday" which both aired on Aug 25, 2020.