Based on the characteristics present in the related genus Euchambersia, Russian paleontologist Mikhail Ivakhnenko raises the possibility that the animal may have had a venom gland.

The imposing size of Megawhaitsia and its position as an apex predator could be linked to the disappearance or absence of large gorgonopsians at the end of the Late Permian in certain regions of present-day European Russia.

The holotype specimen of Megawhaitsia was discovered in the mid-1950s during excavations carried out in the locality of Vyazniki-2, located in Vladimir Oblast, in European Russia, before being cataloged as PIN 1100/101.

Given the low presence of gorgonopsians during the Late Permian in Russia, the fossil was reassigned to a large therocephalian in a work published in 1997, without however receiving a binomial name.

[3] A feature of the maxillary bone is that it has three channels which start in the region of the lacrimo-nasal duct, pass along the roots of the teeth and open near the sockets of each of the canines.

By analogy with the hypotheses on the venomousness of another genus of therocephalians, Euchambersia, Ivakhnenko interprets these canals as a possible proof of the presence of poisonous glands in Megawhaitsia, which would be used to slaughter large prey.

[5] During the second half of the 20th century, the fossil maxillary bones of Megawhaitsia were considered to belong to a gorgonopsid similar or identical to the genus Inostrancevia.

[1] A study published less than a year later by Adam Huttenlocker estimated that the families Euchambersiidae, Moschorhinidae and Annatherapsididae represented junior synonyms of Akidnognathidae, considered the sister-group of Whaitsiidae.

[6] It was in 2016 that Huttenlocker and Christian Sidor concluded that the Akidnognathidae are in fact close to the Chthonosauridae, the two forming the sister-group of a clade containing the Whaitsioidea and the Baurioidea.

It reveals a high content of bony material, including bones bearing traces of a rich network of blood vessels, probably belonging to dicynodonts, indicating a predator that occupied the top position in the trophic chain.