Mehmet Topuz (born 7 September 1983) is a Turkish former professional footballer who played as a midfielder or right-back for Kayserispor and Fenerbahçe.

However, Kayserispor Board strongly asserted that they would not let him go and supported their intentions to keep him in the club by advertising on billboards.

In 2007–08 season, he played two games in UEFA Cup qualification, in which Kayserispor lost against Paris Saint-Germain 2–1 on aggregate.

After playing five years for Kayserispor, he became one of the finest Turkish talents during his time and eventually moved to Turkish giants Fenerbahçe in 2009 for a fee of €9 million + Gökhan Emreciksin following a lengthy transfer battle with fellow rival giants Beşiktaş in which he wore the Beşiktaş jersey after agreeing terms with the club.

Topuz scored his first goal against Twente in the first group game of UEFA Europa League from a freekick at 71st minute.