Mei made his debut on the Main Tour in the 2009/2010 season, as the ACBS Asian nomination, playing his first match at the 2009 Grand Prix.

He lost 5–0 to Patrick Wallace, and was defeated in his next two matches, in the UK Championship and the Welsh Open, to Atthasit Mahitthi and Stephen Rowlings respectively.

Mei recorded his first win as a professional in the 2010 China Open, where he beat Noppadol Sangnil 5–4, having trailed 4–2, but lost in the next round, 5–1 to Robert Milkins.

He reached the last 16 of the Welsh Open with victories over Matthew Selt, Peter Ebdon and Mark Allen, but was beaten 4–2 by Robert Milkins.

Mei returned to China after losing in the 2nd round of the 2020 Gibraltar Open due to the ongoing COVID-19 pandemic, and hasn't entered any events since then.