The Prince was born in Munich, where his father as president acted of the Privy Council for Duke Maximilian I of Bavaria.

He commissioned the renowned architect Michael Beer from Vorarlberg to rebuild and modernize the castles at Sigmaringen and Haigerloch.

In 1633, a Catholic army Under general Gustav Horn had retake the castle, however, during the battle the eastern wing had been destroyed by fire.

He paid this construction work out of his own pocket, using funds he had inherited from his father, and his wife's fortune.

Meinrad married on 7 May 1635 to Anna Marie (1613 – 12 February 1682), the daughter of Baron Ferdinand of Törring at Seefeld, with whom he had nineteen children: