As an actress, she began her career on Israeli television, appearing on Dancing with the Stars, Esti HaMekho'eret (Ugly Betty), and in Romeo and Juliet.

[8] In 1994 Dohan joined the Israel Defense Forces and served in the I.D.F theater, later studying at Nissan Nativ acting school.

A couple of years later, Israeli playwright Edna Mazia wrote a part into her play "Bad Children" specifically for Dohan.

She also began directing at the Tmu-na Theater and co-wrote the original Revue Love Sex on the High Holidays, along with Israeli singer Ivri Lider.

The theatrical performance was Dohan's big break in US-theatre, receiving positive reviews from New York-based media, including the New York Times.

[13] In speaking toward her work with her co-stars, they wrote "Their quick banter and easy back-and-forth are polished and at times charming, and together they make even the most disjointed material a pleasure to watch".

[14] The New York Times also spoke well of Bath Party, comparing Dohan to "a younger, prettier, blonder Rosanna Arquette", noting it as an essentially a one-woman show which "focuses on her not particularly interesting efforts to jump-start an American career, complete with film and television clips, circumlocutory monologues and, perhaps most important for this particular performer, multiple opportunities to reveal her appealing anatomy", and also praising the work of the few others in the cast.

After the first season of the television show Weeds, Dohan secured the role as Yael Hoffman, an Admission director of Ha Midrash L’Torah, the rabbinical school that main character Andy Botwin attended.

[16] In 2008, she appeared in both the Off-Broadway and Los Angeles productions of the play Stitching[1] by controversial British playwright Anthony Neilson and directed by Timothy Haskell, an example of "in-yer-face" theater.

They found that it did not, blaming the Neilson script for working "so hard at being gimmicky that it doesn't give Ms. Dohan and her co-star, Gian Murray Gianino, a chance to find real chemistry.

They granted that the two leads "give energetic, bruise-inducing performances under Timothy Haskell's direction", but that the script's manner of ricocheting "from comedy to pathos to psychosis without ever really providing the starting point that any play needs" placed too many demands on them.

Dohan plays the character Aurora in the online series, which received positive reviews, including one from the Los Angeles Times.

[20] Dohan returned to theatre in January 2011, headlining the Alan Bowne stage play Beirut in a limited revival directed by Andrew and Zach Zoppa in New York City.

[2] Later in the year, Dohan starred in the dramatic thriller Monogamy directed and written by Academy Award nominee Dana Adam Shapiro.

In October 2011, Dohan debuted "Yummy Boyz", a viral video that was featured on pop sites including Popdust.com, which called the tune catchy, upbeat and exuding the same sexiness and playfulness that the actress turned singer represented.

"Yummy Boyz" received rave reviews by entertainment sites across the world,[citation needed] quickly solidifying her as a new gay icon and one of the Top 5 Artists to Watch according to PRIDE Radio and Dinah Shore.

Due to the success of "Yummy", the singer performed at the Winter Music Conference, White Party, and The Dinah, who named Dohan one of the five emerging artists to watch in 2012.

[citation needed] In June 2012, Interview premiered Dohan's second single "On Ya" featuring rapper-singer-songwriter Sean Kingston.

Dohan also released an official video for "On Ya" on 14 October 2012, which included Sean Kingston and which garnered over three million views over one month.