Born in Brooklyn, New York, Mel Brandt’s military records state that he attended college for two years, and his civilian occupation was actor.

His radio announcing credits included The Adventures of Frank Merriwell,[5] Author Meets the Critics, and The Eternal Light.

[7] His introduction was "The Doctors: The Emmy Award winning program, dedicated to the brotherhood of healing."

Brandt was the series announcer for other NBC-TV programs including The Bell Telephone Hour from 1959 through 1968,[8] and GE College Bowl on NBC from 1963–70, in which his introduction was "Match wits with the champions in America's favorite question and answer game, live from New York, the General Electric College Bowl,", and after a brief plug for General Electric would introduce "the man with the questions, Robert Earle.

[12] Mel Brandt was elected president of AFTRA – the American Federation of Television and Radio Artists – from 1967 to 1970.