In 2004 during a tour in Russia, De Biasio suffered from a serious pulmonary infection which caused a loss of singing ability for a full year.

[1] Soon after she graduated, Belgian jazz musician and saxophone professor at her Conservatory Steve Houben asked her to appear in concert with him, allowing her to play in numerous festivals and other large music events in Belgium.

It was favourably received by critics and it won the "Best Jazz Album" award at Les Octaves de la Musique.

In the same year she also won the European Border Breakers Award and the Champagne Price in France, along with the Octave De La Musique, D6BELS and Medaille Chevalier Wallon in Belgium.

The EP's cover artwork contains a black-and-white picture of Melanie De Biasio's home city Charleroi by photographer Stephan Vanfleteren.

While on tour, her track 'I Feel You – Eels Remix' was used to promote the film Alien: Covenant directed by Ridley Scott, it runs during the entire in-universe short movie "Meet Walter" starring Michael Fassbender.

In 2017, in collaboration with a group of 10 patrons of the arts from Charleroi, Melanie De Biasio bought the house built in 1877 for Jules Audent, then mayor of the city.