The album also features production from a collective of producers such as Sicknature and ENG, as well as performance appearances by fellow rap artists such as DZK and Warbucks of Warlab Records, Blaq Poet, K-Solo, and D12, among others.

The conceptual artwork for Melatonin Magik is partly inspired by the feature film The Matrix, depicting Canibus in a meditative posture surrounded by chains and broken glass.

A deluxe edition of Melatonin Magik featuring two bonus tracks, "Wu-Flix" and "Fraternity of the Impoverished (Extended Mix)", the album was released digitally on February 9, 2010.

The song "Air Strike (Pop Killer)" generated controversy as Canibus reignited a feud with longtime rival Eminem and used D12 verses secured by DZK to create the illusion that they had sided with him.

[citation needed] Professor Griff appears on several songs, which was also controversial given his past public statements that led to him being frozen out of the mainstream hip hop scene.