Melbourne is a home rule-class city in Campbell County, Kentucky, United States, along the south bank of the Ohio River.

St. Anne Convent is located in Melbourne; scenes from the movie Rain Man were filmed there.

Melbourne is located in northeastern Campbell County and is bordered by the city of Silver Grove to the west.

Downtown Cincinnati, Ohio, is 11 miles (18 km) to the northwest via Interstate 471.

According to the United States Census Bureau, Melbourne has a total area of 0.78 square miles (2.01 km2), all land.