From an early age she performed with several groups including The Rubi, Girls of Puerto Rico and The Cherries, with whom she appeared in several San Juan hotels.

By 2003, she was also performing as an actress on television movies such as: "Yo Creo en Santa Claus" in 2004, broadcast by Televicentro in Puerto Rico, and Wapa America in the United States, among others, and has received several popular awards and had several successful albums and singles on the Billboard Tropical and Latin charts.

Tropix Music signed her as a solo artist and she released her first album Mujeres Liberadas (Liberated Women) in 1997 which reached the top 10 of the Billboard tropical charts.

This attracted the interest of Sony Music who released her second album Con Los Pies Sobre La Tierra produced by Eduardo Reyes which made both the Billboard Latin and Billboard tropical album charts.

In 2010 Melina Leon won her first Premio Lo Nuestro Award as Best Tropical Female Artist.