Melissa (Calabrian: Mèlissë) is a comune in the province of Crotone, in Calabria.

The village Melissa is situated in the mountainous inland, while the frazione of Torre Melissa is on the Ionian Sea coast.

The Melissa DOC is a Calabrian wine region.

Melissa is mentioned for the first time in 13th century documents.

In 1949 it was the location of a massacre, when the police shot against the population, killing three people.