Melissa Reese (born March 1, 1990) is an American musician who has collaborated frequently with Bryan "Brain" Mantia and is a current member of hard rock band Guns N' Roses.

[4] Reese won an outstanding soloist award at the Lionel Hampton Jazz Festival in high school.

[4] After graduating school, Reese began experimenting with recording, creating a module that featured a Boss BR-8 and a Roland Groovebox.

[8] Three of the songs of the EP were featured in various TV shows, including Gossip Girl and Keeping up with the Kardashians.

Brain and Melissa composed part of the soundtrack in the video game Infamous 2, for which they were nominated for "Outstanding Achievement in Original Composition" by the Academy of Interactive Arts and Sciences awards.

[10] Other video games the duo worked on include PlayStation Home, ModNation Racers, Twisted Metal, Fantasia: Music Evolved and Infamous: Second Son.

They have worked with music video director Joseph Kahn on several television commercials for NASCAR, SEAT, and Qoros.

[14] Reese joined Guns N' Roses in March 2016 as the band's second keyboardist, replacing Chris Pitman, while also playing synthesizer, sub-bass, background vocals, and programming for all electronic sounds during live performances.

"[1] As well as singing backing vocals, Reese's role in the band has been described as the "enhancer", using Akai samplers among other tools to produce sounds from Chinese Democracy songs, as well as playing the Moog synthesizer on "Paradise City".