[1][2] Mark-Viverito was born in Bayamón, Puerto Rico, to Anthony Mark, a physician and founder of San Pablo Hospital, and Elizabeth Viverito.

[16] Mark-Viverito sponsored the bills so that young people in communities of color could "fulfill their potential"[17] by incentivizing officers to give verbal warnings and fines but not remove the option of making arrests.

[20] In 2017, Mark-Viverito declined to boycott the Puerto Rican Day Parade, after organizers decided to honor Oscar López Rivera, a prominently incarcerated member of Fuerzas Armadas de Liberación Nacional Puertorriqueña (FALN).

[23] In August 2019, Mark-Viverito announced her candidacy to replace José E. Serrano as representative of New York's 15th Congressional District,[24] but lost in the primary to Ritchie Torres, receiving 4.3% of the vote with a rank of 6th place.

[25] Mark-Viverito campaigned in solidarity with the Occupy Wall Street movement and identified herself as part of the "99%" of income earners despite having a net worth in the millions.

[28] In 2016, in response to the Donald Trump's Access Hollywood tape recording, Mark-Viverito public revealed that she had been a victim of childhood sexual abuse, drawing the support of many, including other elected officials.