Prignano Cilento is a town and comune in the province of Salerno in the Campania region of south-western Italy.

[2] Prignano is located in northern Cilento and borders with the municipalities of Agropoli (10 km west), Cicerale, Ogliastro Cilento (4 km north), Perito, Rutino and Torchiara.

[4][5] It counts the hamlets of (frazioni) Melito and San Giuliano; and the rural localities of Acquabona, Alento, Selva and Serre.

Until the end of the 16th century, it existed another hamlet named Poglisi (or Puglisi).

[7] The town is crossed in the middle by the state highway SS18, and is served by the SS18 Var highway, linking Salerno to Sapri (via Battipaglia, Agropoli and Vallo della Lucania), at the homonym exit.