Melle (German: [ˈmɛlə] ⓘ) is a city in the district of Osnabrück, Lower Saxony, Germany.

In 1443 Heinrich von Moers, Bishop of Osnabrück, gave Melle the privilege of a Wigbold.

Melle is situated in a valley penned between the Wiehen Hills in the North and the Teutoburg Forest in the South.

The city consists of the eight municipalities of Melle-Mitte, Buer, Bruchmühlen, Gesmold, Neuenkirchen, Oldendorf, Riemsloh and Wellingholzhausen.

The EXPO 2000 observatory in Melle-Oberholsten runs the largest Newtonian telescope used for public observation.