The Mellon National Bank Building at 500 Smithfield Street in downtown Pittsburgh, Pennsylvania, was completed in 1924 after Mellon acquired the property in August 1916 from the Baltimore & Ohio Railroad which had their regional offices on the site.

[3] Prior to the B&O office the site was the original home to the city's first public high school (Central High), which opened in the fall of 1855.

[4] The Classical-styled building was designed by architects Trowbridge & Livingston with Edward Mellon.

It was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 1976,[2] and the List of City of Pittsburgh historic designations in July 1999.

On May 31, 2012 PNC Financial Services purchased the structure[7] and converted it to a call center.