Melmoth is the fifth novel in Canadian cartoonist Dave Sim's Cerebus comic book series.

After Jaka, Rick and Oscar's arrest (and Pud's death), Cerebus returns to the Lower City, where he uses a gold coin to buy room and board at Dino's for the rest of his life.

There were also brief appearances by numerous characters from the series, including the Roach, Mick & Keef, Posey and others.

It included an 11-page text section with reproductions of letters from The Collected Letters of Oscar Wilde that Sim used as the basis for the Wilde portions of the story, showing the changes he made to make them fit into the fictional world of Estarcion, plus annotations.

The first printing, October 1991, was a signed (by both Dave Sim and Gerhard) and numbered (out of 410) by hand on the inside title page.