Melrose House is a stately mansion and museum located opposite Burgers Park in Pretoria, South Africa.

Built in 1886 by the prosperous Pretoria businessman George Jesse Heys, it was named after the famous Melrose Abbey in Scotland.

Melrose House gained fame during the Second Boer War (1899–1902) when Lord Roberts requisitioned it as the headquarters for the British forces after Pretoria was invaded in June 1900.

The Pretoria City Council purchased the house and its contents in 1967 for R300,000 for restoration, culminating in State President of South Africa Charles Robberts Swart opening it as a museum and declaring it a national heritage site on May 17, 1971.

Notably the museum contains the room and the table on which the Treaty of Vereeniging (which ended the Second Boer War) was signed.