[1] Mel De Lloyd began his rugby union career playing alongside his brothers at Resolven RFC, aged seventeen he then played alongside Bill Clement for Llanelli RFC, he was spotted by Eddie Waring, and was recommended to rugby league club Warrington, he made his début for Warrington on Saturday 26 September 1936, he played stand-off in Warrington's 8-4 victory over Barrow in the 1937 Lancashire Cup Final during the 1936–37 season at Central Park, Wigan on Saturday 23 October 1937.
on Saturday 3 January 1942 he was sent off after disputing a decision by the referee, Mr L. Dolby, alleged that De Lloyd had later "struck him".
On Wednesday 7 January 1942, the Rugby Football League disciplinary committee suspended De Lloyd indefinitely (sine die).
The suspension was lifted 10-months later in October 1942, he resumed playing having missed 14-games, he scored 1-try, 3-conversions, and 3-drop goals for a total of 15-points in the 21-0 victory over Huddersfield in the first leg of the 1943 Yorkshire Cup semi-final during the 1943–44 season at Lawkholme Lane on Saturday 13 November 1943, during his time at Keighley they appeared in two Yorkshire Cup finals, the only Yorkshire Cup finals that Keighley have appeared in, the 7-10 aggregate defeat (2-5 at Odsal Stadium on Saturday 27 November 1943, and 5-5 at Lawkholme Lane on Saturday 4 December 1943) to Bradford Northern in the 1943 Yorkshire Cup Final during the 1943–44 season, and the 3-17 defeat by Wakefield Trinity in the 1951 Yorkshire Cup Final during the 1951–52 season at Fartown Ground, Huddersfield on Saturday 27 October 1951, after the war he resumed playing for Warrington, playing his last game for them on Saturday 11 October 1947, he then signed for Keighley in 1947, eventually retiring from playing in 1952.
Mel De Lloyd's marriage to Thelma (née Smith) was registered during first ¼ 1940 in Warrington district,[6] and his marriage to Mary Fagan was registered during fourth ¼ 1948 in Newton district,[7] he is buried alongside his second wife in St. David's Cemetery, Resolven.