Menashi (目梨郡, Menashi-gun) is a district located in Nemuro Subprefecture, Hokkaido, Japan.

The local government in Nemuro, which includes Shiretoko and The Northern Territories, decided to name the whole region "Menashi".

In the first year of the Kansei Era (1789) the native inhabitants rebelled in Kunashiri and Menashi resulting in the Kansei-Ezo Uprising (kansei ezo hōki 寛政蝦夷蜂起) and the deaths of a large number of Japanese people (wajin 和人.)

The shōgun assumed control and established more of a presence in the Menashi region around 1799 (Kansei 11) due to Russia's menacing southern expansion policies.

In c. 1855 (Ansei 2) Menashi fell under the domain of the shōgun once again via the Aizu clan, who ruled the area severely.