This course taught bookkeeping, penmanship, arithmetic, algebra, English grammar and composition, elocution, geography, history, German, business practice, and commercial law and was stable for several years.

The main program offered was a four-year Bachelor of Philosophy in Commerce with classes in accounting for four semesters and additional classes in money, credit and banking, public finance, economic development in the United States, railway transportation, industrial organization and combination, insurance, and business law.

Additional coursework included several foreign languages, economics, philosophy, politics, labor problem, American government, and elocution.

He hoped to place Notre Dame and its graduates in the burgeoning trade and growing economic power between North and South America.

Under O'Hara's leadership, the school soon offered 85 classes in 5 departments (accounting, marketing, transportation, finance, and foreign trade) and his efforts, together with a societal trend towards valuing business education to obtain a job, made the college tie the College of Arts and Letters as the highest enrollment in 1922 with over 500 students.

Despite criticism that the college's education was becoming too commercialized and vocational, O'Hara maintained a liberal arts theme in the business courses and retained language, philosophy, political science, and history classes.

O'Hara's ambitious goals (which included a graduate school and major program in foreign commerce) were cut short by lack of funding.

Located just southwest of the Notre Dame Stadium, it was designed following a nautical motif and nicknamed "the ship of commerce".

In March 2000, the College of Business received a naming gift from NetApp, Inc. executives, Tom and Kathy Mendoza.

[14][15] Poets & Quants reveals a placement rate of 93% after 3 months for the Undergraduate school, as well as an average starting salary of roughly $72,000.

The Mendoza College of Business main building, located on DeBartolo Quad, was built in 1996 and designed by Ellerbe Becket.

The Stayer Center for Executive Education, built between 2011 and 2013 and located immediately south of the main Mendoza building, hosts both the degree and non-degree programs aimed at the executive-level MBA students and corporate clients.

It is built in collegiate architecture style and was designed by Robert A.M. Stern Architects, and features stained glass windows.