The serial features Nauman Ijaz, Savera Nadeem, Aamina Sheikh, Beenish Chohan and Sunita Marshall in leading roles.

Mera Saaein is the story of a traditional feudal lord and politician with insatiable desires of women, power and wealth.

He makes the secretive 3rd wife go through an abortion, divorces her and sends her and the 2 daughters away when he finds out that the gender of the unborn child is a female.

When he meets the UK returned Shazmeen, he is instantly attracted and tricks her into falling in love with him and breaking off her engagement to marry him.

Over time, Shazmeen produces 3 daughters and discovers Malik Wajahat's past and true face and the marriage deteriorates.

It focused on the rivalry between Naina (Aamina Sheikh) and Shazmeen (Sunita Marshall) who are supposed to be best friends at one time but later fight for political powers along with their respective husbands played by Waseem Abbas and Shahood Alvi.

The cast also included Fahad Mustafa along with Mahnoor Baloch, Ayeza Khan, Zhalay Sarhadi and Anoushay Abbasi.