The OM457 has many applications, including trucks, marine, military, municipal, bus and agricultural vehicles, as well as stationary settings.

The engine has many differing trim and power levels, ranging from around 250 to 450 horsepower, as well as both a vertically-mounted and, for buses, a horizontally-mounted version (denominated OM 457 hLA).

The engine utilizes diesel fuel delivered in a direct injection method from individual electronically-controlled and camshaft-actuated unit pumps.

The crankshaft is a precision forged unit running in seven three-layer bearings, with counterweights bolted onto the crank webs, much like any other diesel motor of its vintage.

The connecting rods are of a split design, with bronze bushings for the piston pin.