Merestone, also known as the John S. Reese, IV, House, is an American historic estate that is located in New Garden Township, Chester County, Pennsylvania, and New Castle County, Delaware.

[1] Renovated and added to by architect R. Brognard Okie, this historic structure features elements of the Colonial Revival style.

The original log section of Merestone House dates to roughly between 1720 and 1734.

A two-story, one-bay, wing was added roughly between 1802 and 1806.

At the same time, Okie built the 1+1⁄2-story, three-bay, frame, guest house/garage on the stone foundation of a barn that dated to 1806.