She is best known for performing in Broadway musicals such as Jesus Christ Superstar, Spamalot, Rent, and Once on This Island, as well as her video game roles as Alyx Vance in Half-Life 2 and Marlene in The Last of Us franchise.

She attended Papillion La Vista High School and participated in the play production class and theater department there.

[4] Dandridge also had the recurring roles in the FX drama series, Sons of Anarchy as Rita Roosevelt, and short-lived The CW teen soap Star-Crossed in 2014.

[5] In 2015, Dandridge was cast as the lead character in the Oprah Winfrey Network drama series, Greenleaf opposite Lynn Whitfield.

[8][9][10] From November 9, 2017, to January 7, 2018, Dandridge starred as Papa Ge the God of Death in the Broadway musical revival of Once on This Island,[11] at the Circle in the Square Theater.

[18] On January 9, 2025, it was announced that Dandridge would be taking over the role of Persephone in the Broadway production of Hadestown starting February 18.