Starting in 1958, Merrill and three of his brothers (Alan, Wayne, and Jay in their respective age orders) began singing as a barbershop quartet.

In 1962, the four Osmonds were regular guests over a seven-year period on NBC's The Andy Williams Show, a musical variety program.

They also appeared in nine episodes of the 1963–64 ABC western television series The Travels of Jaimie McPheeters, with Merrill in the role of young Deuteronomy Kissel.

[6] Osmond has sporadically hosted the podcast Sound Advice with his son Justin since 2020, produced by KSL radio.

A statement of faith on his Web site expresses support for the Book of Mormon and the prophecies of Joseph Smith, as well as the church's compatibility with mainstream Christianity.